> For the complete documentation index, see [llms.txt](https://wintermute.gitbook.io/docs/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://wintermute.gitbook.io/docs/synthetic-biologist.md).

# Synthetic Biologist

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### Harvard Systems Biology

I have a PhD in Systems Biology from Harvard Medical School. I worked in Pam Silver's lab and wrote my thesis about engineering microbial metabolism.
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### Université Paris Cité

From 2010-2021 I was a postdoc and research group leader at the CRI in Paris (since renamed the [LPI](https://maps.app.goo.gl/kyLYKhzCXL9rua228)). My lab studied antimicrobial resistance and built tools to make drug discovery cheaper.
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### Synthetic Biology One

In 2018 I created a 61-episode [YouTube series](https://www.youtube.com/@syntheticbiologyone1519) dedicated to teaching core techniques and concepts in synthetic biology. As of 2025 it has 20,000+ subscribers and 1 million+ total views.

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### My Publications

My journal publications are under my legal name, Edwin. (ORCID: [0000-0002-4211-1716](https://orcid.org/0000-0002-4211-1716))

<table data-view="cards"><thead><tr><th></th><th data-hidden data-card-cover data-type="files"></th><th data-hidden data-card-target data-type="content-ref"></th></tr></thead><tbody><tr><td>The iGEM Grand Jamboree and the Serious Fun of Engineering Biology (2025). <a href="https://pubs.acs.org/doi/10.1021/acssynbio.5c00083">ACS Synthetic Biology</a></td><td><a href="/files/lEHAeKp7Vxb5vxyMF82B">/files/lEHAeKp7Vxb5vxyMF82B</a></td><td></td></tr><tr><td><strong>Spatial engineering of </strong><em><strong>E. coli</strong></em><strong> with addressable phase-separated RNAs (2022).</strong> <a href="https://www.cell.com/cell/fulltext/S0092-8674(22)01174-6"><strong>Cell</strong></a></td><td><a href="/files/mcgDSkuhXoo3D3pEVUu3">/files/mcgDSkuhXoo3D3pEVUu3</a></td><td><a href="https://www.cell.com/cell/fulltext/S0092-8674(22)01174-6">https://www.cell.com/cell/fulltext/S0092-8674(22)01174-6</a></td></tr><tr><td>Low-cost anti-mycobacterial drug discovery using engineered E. coli (2022). <a href="https://www.nature.com/articles/s41467-022-31570-3">Nature Communications</a></td><td><a href="/files/d4Buv21NfNfL93W364XL">/files/d4Buv21NfNfL93W364XL</a></td><td></td></tr><tr><td><strong>Empowering grassroots innovation to accelerate biomedical research (2021).</strong> <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001349"><strong>PLoS Biology</strong></a></td><td><a href="/files/d0QRqJilmm344lNmUMKK">/files/d0QRqJilmm344lNmUMKK</a></td><td><a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001349">https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001349</a></td></tr><tr><td>A survival model for course-course interactions in a Massive Open Online Course platform (2021). <a href="https://doi.org/10.1371/journal.pone.0245718">PLoS ONE</a>.</td><td><a href="/files/eEskgVToVOwwpnLMAsGk">/files/eEskgVToVOwwpnLMAsGk</a></td><td><a href="https://doi.org/10.1371/journal.pone.0245718">https://doi.org/10.1371/journal.pone.0245718</a></td></tr><tr><td><strong>The smell of us – crowdsourcing human body odor evaluation (2016).</strong> <a href="https://hcjournal.org/index.php/jhc/article/view/81"><strong>Human Computation</strong></a></td><td><a href="/files/vjizTLjaeOHjLefXwB7s">/files/vjizTLjaeOHjLefXwB7s</a></td><td><a href="https://hcjournal.org/index.php/jhc/article/view/81">https://hcjournal.org/index.php/jhc/article/view/81</a></td></tr><tr><td><strong>Phage-mediated Delivery of Targeted sRNA Constructs to Knock Down Gene Expression in </strong><em><strong>E. coli</strong></em><strong>. (2016).</strong> <a href="https://app.jove.com/t/53618/phage-mediated-delivery-targeted-srna-constructs-to-knock-down-gene"><strong>JOVE</strong></a></td><td><a href="/files/lWjdwm0vIbuTDU4zX0KG">/files/lWjdwm0vIbuTDU4zX0KG</a></td><td></td></tr><tr><td><strong>In situ characterization of mycobacterial growth inhibition by lytic enzymes expressed in vectorized </strong><em><strong>E. coli</strong></em><strong>. (2014)</strong> <a href="https://pubs.acs.org/doi/10.1021/sb500039z"><strong>ACS Synthetic Biology</strong></a></td><td><a href="/files/LUdzm1KYE1lzXZuPWYrr">/files/LUdzm1KYE1lzXZuPWYrr</a></td><td><a href="https://pubs.acs.org/doi/10.1021/sb500039z">https://pubs.acs.org/doi/10.1021/sb500039z</a></td></tr><tr><td><strong>Silencing of antibiotic resistance in </strong><em><strong>E. coli</strong></em><strong> with engineered phage bearing small regulatory RNAs. (2014)</strong> <a href="https://pubs.acs.org/doi/10.1021/sb500033d"><strong>ACS Synthetic Biology</strong></a></td><td><a href="/files/kcGSv77J6qks6YDHFBnh">/files/kcGSv77J6qks6YDHFBnh</a></td><td><a href="https://pubs.acs.org/doi/10.1021/sb500033d">https://pubs.acs.org/doi/10.1021/sb500033d</a></td></tr><tr><td><strong>An objective function exploiting suboptimal solutions in metabolic networks (2013).</strong> <a href="https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-7-98"><strong>BMC Systems Biology</strong></a></td><td><a href="/files/vPvyycWdHqhmi9MvyjGG">/files/vPvyycWdHqhmi9MvyjGG</a></td><td><a href="https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-7-98">https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-7-98</a></td></tr><tr><td><strong>A synthetic system links FeFe-hydrogenases to essential </strong><em><strong>E. coli</strong></em><strong> sulfur metabolism. (2011)</strong> <a href="https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-5-7"><strong>Journal of Biological Engineering</strong></a></td><td><a href="/files/uNUDu3i8oYZGCegTx2D9">/files/uNUDu3i8oYZGCegTx2D9</a></td><td></td></tr><tr><td><strong>Dynamics in the mixed microbial concourse. (2010)</strong> <a href="https://genesdev.cshlp.org/content/24/23/2603"><strong>Genes &#x26; Development</strong></a></td><td><a href="/files/HX4dclpuBOk7H2cph8qp">/files/HX4dclpuBOk7H2cph8qp</a></td><td><a href="https://genesdev.cshlp.org/content/24/23/2603">https://genesdev.cshlp.org/content/24/23/2603</a></td></tr><tr><td><strong>Emergent cooperation in microbial metabolism. (2010)</strong> <a href="https://www.embopress.org/doi/full/10.1038/msb.2010.66"><strong>Molecular Systems Biology</strong></a></td><td><a href="/files/c8BpR7gmMDoYPIT3jtGx">/files/c8BpR7gmMDoYPIT3jtGx</a></td><td><a href="https://www.embopress.org/doi/full/10.1038/msb.2010.66">https://www.embopress.org/doi/full/10.1038/msb.2010.66</a></td></tr><tr><td><strong>Insulation of a synthetic hydrogen metabolism circuit in bacteria. (2010)</strong> <a href="https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-4-3"><strong>Journal of Biological Engineering</strong></a></td><td><a href="/files/HIFZtniKYIwTvfqWbRtD">/files/HIFZtniKYIwTvfqWbRtD</a></td><td></td></tr><tr><td>Hierarchical structure in the <em>Drosophila mojavensis</em> cluster. (2004) <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-5223.2003.01761.x">Hereditas</a></td><td><a href="/files/aJWZRGwrwVbLXsN4nVV9">/files/aJWZRGwrwVbLXsN4nVV9</a></td><td><a href="/pages/RqfRc8g4aaWm8LvkgLHT">/pages/RqfRc8g4aaWm8LvkgLHT</a></td></tr></tbody></table>