> For the complete documentation index, see [llms.txt](https://wintermute.gitbook.io/docs/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://wintermute.gitbook.io/docs/synthetic-biologist.md). # Synthetic Biologist My academic life from 2010-2022 {% columns %} {% column width="50%" %} ### Harvard Systems Biology I have a PhD in Systems Biology from Harvard Medical School. I worked in Pam Silver's lab and wrote my thesis about engineering microbial metabolism. {% endcolumn %} {% column %}
{% endcolumn %} {% endcolumns %} {% columns %} {% column width="50%" %} ### Université Paris Cité From 2010-2021 I was a postdoc and research group leader at the CRI in Paris (since renamed the [LPI](https://maps.app.goo.gl/kyLYKhzCXL9rua228)). My lab studied antimicrobial resistance and built tools to make drug discovery cheaper. {% endcolumn %} {% column %}
{% endcolumn %} {% endcolumns %} {% columns %} {% column %} ### Synthetic Biology One In 2018 I created a 61-episode [YouTube series](https://www.youtube.com/@syntheticbiologyone1519) dedicated to teaching core techniques and concepts in synthetic biology. As of 2025 it has 20,000+ subscribers and 1 million+ total views. {% endcolumn %} {% column %} {% embed url="" %} {% endcolumn %} {% endcolumns %} ### My Publications My journal publications are under my legal name, Edwin. (ORCID: [0000-0002-4211-1716](https://orcid.org/0000-0002-4211-1716))
The iGEM Grand Jamboree and the Serious Fun of Engineering Biology (2025). ACS Synthetic Biology2025-wintermute-igem.jpg
Spatial engineering of E. coli with addressable phase-separated RNAs (2022). Cellcell-2022.jpghttps://www.cell.com/cell/fulltext/S0092-8674(22)01174-6
Low-cost anti-mycobacterial drug discovery using engineered E. coli (2022). Nature Communications2022-natcomm.jpg
Empowering grassroots innovation to accelerate biomedical research (2021). PLoS Biology2021-plos.jpghttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001349
A survival model for course-course interactions in a Massive Open Online Course platform (2021). PLoS ONE.2021-plosone.jpghttps://doi.org/10.1371/journal.pone.0245718
The smell of us – crowdsourcing human body odor evaluation (2016). Human Computation2016-human-comp.jpghttps://hcjournal.org/index.php/jhc/article/view/81
Phage-mediated Delivery of Targeted sRNA Constructs to Knock Down Gene Expression in E. coli. (2016). JOVE2016-jove.jpg
In situ characterization of mycobacterial growth inhibition by lytic enzymes expressed in vectorized E. coli. (2014) ACS Synthetic Biology2014-acs-synbio.jpghttps://pubs.acs.org/doi/10.1021/sb500039z
Silencing of antibiotic resistance in E. coli with engineered phage bearing small regulatory RNAs. (2014) ACS Synthetic Biology2014b-acs-synbio.jpghttps://pubs.acs.org/doi/10.1021/sb500033d
An objective function exploiting suboptimal solutions in metabolic networks (2013). BMC Systems Biology2013-bmc.jpeghttps://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-7-98
A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism. (2011) Journal of Biological Engineering2011-jbe.jpeg
Dynamics in the mixed microbial concourse. (2010) Genes & Development2010-genesdev.jpghttps://genesdev.cshlp.org/content/24/23/2603
Emergent cooperation in microbial metabolism. (2010) Molecular Systems Biology2010-msb.jpghttps://www.embopress.org/doi/full/10.1038/msb.2010.66
Insulation of a synthetic hydrogen metabolism circuit in bacteria. (2010) Journal of Biological EngineeringScreenshot 2025-07-09 at 2.53.16 PM.png
Hierarchical structure in the Drosophila mojavensis cluster. (2004) Hereditashrd2_1761_f2.gifHi! I'm Jake Wintermute